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The toxic dose of barbiturates differs noticeably. On the whole, an oral dose of 1 gram of most barbiturates makes critical poisoning within an adult.
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Barbiturates are substituted pyrimidine derivatives in which The fundamental framework frequent to those medicines is barbituric acid, a compound that has no central nervous process (CNS) activity. CNS activity is received by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.
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MAOI lengthen the consequences of barbiturates in all probability due to the fact metabolism on the barbiturate is inhibited.